ABSTRACT
This study was designed to investigate the effect of metformin and flutamide alone or in combination with anthropometric indices and laboratory tests of obese/overweight PCOS women under hypocaloric diet. This single blind clinical trial was performed on 120 PCOS women. At the beginning, hypocaloric diet was recommended for the patients. After one month while they were on the diet, the patients were randomly divided in 4 groups; metformin [500 mg, 3/day], flutamide [250 mg, 2/day], combined, metformin [500 mg, 3/day] with flutamide [250 mg, 2/day] and finally placebo group. The patients were treated for 6 months. Anthropometric indices and laboratory tests [fasting and glucose-stimulated insulin levels, lipid profile and androgens] were measured. A one-way ANOVA [Post Hoc] and paired t-test were performed to analyze data. A p